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Optimizing Liquid–Liquid Mixing Scale-Up for Consistent Drop Size and Mass Transfer Using VisiMix

May 4, 2026

Introduction
• Liquid–liquid mixing is a key operation in processes such as extraction, emulsification, and multiphase reactions,
where performance is strongly influenced by droplet size distribution and interfacial area. In such systems, two
competing phenomena—droplet break-up and coalescence—occur simultaneously, and their balance determines
the overall mass transfer efficiency and process outcome.
• While achieving the desired emulsification is often feasible at the laboratory or pilot scale, scaling up to industrial
reactors introduces significant challenges. Changes in vessel geometry, impeller design, and energy dissipation can
alter local hydrodynamics, leading to variations in drop size, mixing time, and ultimately process performance.
• VisiMix provides a robust platform to analyze and predict mixing behavior by evaluating key parameters such as
stabilization time, drop size distribution, and specific mass transfer area. This enables engineers to ensure that
production-scale performance closely matches pilot-scale results, reducing risk and improving scale-up reliability.

PrevPrevious NewsletterGas–Liquid Mixing: Why Higher RPM Is Not Always Better
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Mixing Simulation software for Chemical and Process Engineers.

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