Integrated Reaction Kinetics and Mixing Simulation of a Complex Five-Step Enzymatic Reaction Using VisiMix Chem
Introduction Complex enzymatic reactions in continuous reactors involve intricate interactions between reactants, enzyme activity, intermediate complex formation, and competitive side reactions. The performance of such systems depends on the dynamic evolution of concentration fields, reaction pathways, and hydrodynamic conditions throughout the reactor volume.Accurate prediction of these phenomena requires an integrated approach that captures both the […]
Scaling-Up Emulsification Using Multi- Stage In-Line Rotor–Stator Devices
Emulsification is a critical unit operation in many chemical, pharmaceutical, and specialty manufacturing processes, where product performance and stability are strongly influenced by droplet size distribution. While pilot- scale trials can demonstrate technical feasibility, scaling up to higher throughputs often introduces challenges such as increased droplet coalescence, non-uniform energy dissipation, and loss of product consistency. […]
Beyond Top-Mounted Agitators: Modeling Inclined and Off-Centre Bottom-Entering Shafts Using VisiMix
Mixing performance is strongly influenced not only by impeller type and speed, but also by shaft orientation and entry location. While top-mounted agitators are commonly used, many industrial processes—such as low and high-viscosity mixing, crystallization, and solid-handling operations—often require inclined or bottom-entering shaft configurations due to process, mechanical, or space constraints. VisiMix is not limited […]
Solving a Batch Reactor Scale-Up Failure Using VisiMix
Introduction Scaling up a batch reaction from pilot to production scale often presents challenges that are not immediately evident during development. Even when standard scale-up criteria such as geometric similarity and equivalent mixing time are applied, differences in local hydrodynamics can significantly influence reaction selectivity and product quality. These subtle variations—particularly in reactant distribution and […]
Optimizing Hydrogenation Scale-up with VisiMix: A Gas-Liquid Mixing Case study
Introduction Hydrogenation is a vital process in fine chemical and pharmaceutical manufacturing, playing a key role in producing high-value intermediates and active ingredients. The efficiency of this reaction depends on how effectively hydrogen gas disperses and transfers into the liquid phase. When gas–liquid mixing is inadequate, it can lead to slower reactions, incomplete conversion, and […]
Sensitivity Analysis for Optimizing Liquid–Solid : Mixing Using VisiMix
VISIMIX NEW PRODUCT: SENSITIVITY ANALYSIS The Sensitivity Analysis module in VisiMix is designed to help engineers systematically evaluate how variations in a single process parameter impact overall process performance. In this module, multiple simulations are run in identically designed mixing tanks, where all parameters remain constant except for the one chosen sensitivity variable. Users can […]