Introduction
• Dissolution is a critical operation in many pharmaceutical, chemical, food, and specialty chemical manufacturing
processes. The rate at which solid particles dissolve directly influences batch cycle time, product quality, process
consistency, and overall manufacturing efficiency.

• Although increasing agitator speed is often considered the simplest solution for improving dissolution, the process is
governed by several interacting factors, including particle suspension, liquid-solid mass transfer, impeller geometry,
and flow circulation within the vessel. Poor mixing can lead to particle settling, prolonged dissolution times, and
increased energy consumption.

• In this month’s case study, we demonstrate how VisiMix was used to evaluate a liquid-solid dissolution process,
identify the causes of poor dissolution performance, and optimize the impeller design to achieve complete particle
suspension and significantly reduce dissolution time without increasing the operating speed.